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. 2022 Nov 16;62(13):1921–1929. doi: 10.2169/internalmedicine.0612-22

Table 2.

Baseline Characteristics of Patients and the Clinical Background of the Third-generation and Non-third-generation Cephalosporin Treatment Groups after Propensity Score Matching.

Variable Third-generation cephalosporins
(n=53)
Non-third-generation cephalosporins
(n=53)
p value
Age, ≥65 years; n (%) 42 (79.2) 37 (69.8) 0.373a
Sex, Male (%) 36 (67.9) 38 (71.7) 0.833a
Charlson Comorbidity Index; median (IQR) 3.0 (2.0-4.0) 3.0 (2.0-5.0) 0.369b
Disseminated intravascular coagulation; n (%) 6 (11.3) 7 (13.2) 1.000a
Anticancer agents or immunosuppressants; n (%) 24 (45.3) 21 (39.6) 0.695a
Source of Infection
Lower gastrointestinal tract or intra-abdominal; n (%) 3 (5.7) 4 (7.5) 1.000a
Biliary tract; n (%) 21 (39.6) 22 (41.5) 1.000a
Urinary tract; n (%) 13 (24.5) 14 (26.4) 1.000a
Respiratory system; n (%) 3 (5.7) 0 (0) 0.243a
Intravenous catheter; n (%) 2 (3.8) 0 (0) 0.495a
Unclear or others; n (%) 11 (20.8) 13 (24.5) 0.817a
Clinical characteristics
eGFR, mL/min/1.73 m2; median (IQR) 55.0 (36.0-70.0) 59.0 (42.3-73.7) 0.774b
WBC, /μL; median (IQR) 7,600 (4,300-9,800) 8,500 (4,700-11,500) 0.822b
CRP (≥15), mg/dL; n (%) 5 (9.4) 6 (11.3) 1.000a
Pitt Bacteremia Score (≥4 points); n (%) 16 (30.2) 19 (35.8) 0.680a
Implementation of source control; n (%) 21 (39.6) 22 (41.5) 1.000a
Duration of antimicrobial administration, days; median (IQR) 13.0 (9.0-16.0) 13.0 (9.0-15.0) 0.869b
Microorganisms
Enter obacter cloacae or Enterobacter cloacae complex; n (%) 36 (67.9) 34 (64.2) 0.838a
Klebsiella aero genes; n (%) 14 (26.4) 16 (30.2) 0.830a
Other Enterobacter spp.; n (%) 3 (5.7) 3 (5.7) 1.000a

aFisher’s exact test, bMann-Whitney U test. IQR: interquartile range, eGFR: estimated glomerular filtration rate, WBC: white blood cell, CRP: C-reactive protein