Table II.
Clinical characteristics of patients with Pseudomonas aeruginosa infections via univariate analysis
| MDR (n=77) | NDR (n=181) | P-value | |
|---|---|---|---|
| Age (mean + SD) | 58.3 + 21 | 55.9 + 23 | 0.434 |
| Sex | 0.035 | ||
| Male | 55 (71%) | 104 (57%) | |
| Female | 22 (29%) | 77 (43%) | |
| Year | 0.015 | ||
| 2019 | 37 (48%) | 118 (65%) | |
| 2020 | 40 (52%) | 63 (35%) | |
| History | |||
| Hospitalization in the past 30 days | 35 (45%) | 60 (33%) | 0.061 |
| Antibiotics in the past 30 days | 60 (78%) | 92 (51%) | 5.18E-05 |
| Hospitalization | |||
| Length of hospitalization (mean + SD) | 43.8 + 40 | 24.1 + 33 | 2.47E-04 |
| Length of ICU stay (mean + SD) | 17.2 + 23 | 10.1 + 21 | 0.020 |
| Days of hospitalization till isolate [median (IQR)] | 15 (33) | 1 (8) | 2.56E-09 |
| Isolate obtained within 2 days of admission | 19 (25%) | 111 (61%) | 7.14E-08 |
| Isolated with other organisms (mean + SD) | 1.3 + 0.6 | 1.6 + 0.9 | 0.001 |
| Died in hospital1 | 12 | 19 | 0.047 |
| Location prior to admission | 0.067 | ||
| Home | 52 (68%) | 146 (81%) | 0.134 |
| Nursing home | 13 (17%) | 20 (11%) | 1.000 |
| Other | 12 (16%) | 15 (8%) | 0.479 |
| Isolation site | 4.42E-04 | ||
| Respiratory (all) | 46 (60%) | 58 (32%) | 3.33E-04 |
| Respiratory with Mechanical ventilation | 43 (56%) | 52 (29%) | 1.000 |
| Urine (all) | 15 (19%) | 49 (27%) | 1.000 |
| Urine with Foley/nephrostomy/suprapubic catheter | 5 (33%) | 21 (43%) | 1.000 |
| Wound | 6 (8%) | 43 (24%) | 0.028 |
| Blood | 5 (6%) | 21 (12%) | 1.000 |
| Other | 7 (9%) | 12 (6%) | 1.000 |
| Ward | 0.002 | ||
| ICU | 27 (35%) | 45 (25%) | 0.946 |
| ED | 6 (8%) | 51 (28%) | 0.003 |
| Outpatient | 3 (4%) | 15 (8%) | 1.000 |
| Pediatric | 2 (3%) | 6 (3%) | 1.000 |
| General Med-Surg | 39 (51%) | 64 (35%) | 0.218 |
| Comorbidities | |||
| Charlson Comorbidity Index | 5.79 + 3 | 4.9+ 3 | 0.062 |
| Cancer | 14 (18%) | 22 (12%) | 0.201 |
| Chronic kidney disease | 30 (39%) | 64 (35%) | 0.582 |
| Chronic obstructive pulmonary disease | 5 (7%) | 14 (8%) | 0.920 |
| Congestive heart failure | 11 (14%) | 25 (14%) | 0.920 |
| COVID-19 | 8 (10%) | 15 (8%) | 0.588 |
| Diabetes | 37 (48%) | 81 (45%) | 0.626 |
| HIV/AIDS | 5 (6%) | 8 (4%) | 0.700 |
| Immunosuppressive therapy | 22 (29%) | 50 (28%) | 0.801 |
IQR = interquartile range, SD = standard deviation, ICU = intensive care unit, ED = emergency department. MDR = multi-drug resistant, NDR = non-multi drug resistant.
1
MDR/NDR status of deceased patients based on most recent isolate prior to death for each hospitalization.