TABLE 7.
Multivariate analysis for MCID in patients with low BMI.
| Variables | MCIDa | MCIDb | ||||||
|---|---|---|---|---|---|---|---|---|
| OR (95%CI) | p-values | aOR (95%CI) | aP | OR (95%CI) | p-values | aOR (95%CI) | aP | |
| values | values | |||||||
| Therapy | ||||||||
| LAMA | Reference | Reference | 1.46 (0.36–5.95) | 0.599 | 1.71 (0.34–8.56) | 0.512 | ||
| LABA+ICS | 0.69 (0.17–2.80) | 0.599 | 0.58 (0.12–2.92) | 0.512 | Reference | Reference | ||
| LABA+LAMA | 4.00 (1.28–12.52) | 0.017 | 3.95 (1.04–15.00) | 0.043 | 5.83 (1.26–26.95) | 0.024 | 6.78 (1.16–39.71) | 0.034 |
| LABA+LAMA+ICS | 2.53 (1.05–6.07) | 0.038 | 3.21 (1.10–9.38) | 0.033 | 3.68 (0.96–14.13) | 0.057 | 5.50 (1.09–27.73) | 0.039 |
| Age | 1.02 (0.98–1.06) | 0.438 | 1.01 (0.96–1.07) | 0.653 | 1.02 (0.98–1.06) | 0.438 | 1.01 (0.96–1.07) | 0.653 |
| Sex | ||||||||
| Male | Reference | Reference | Reference | Reference | ||||
| Female | 1.72 (0.62–4.77) | 0.299 | 2.48 (0.45–13.73) | 0.298 | 1.72 (0.62–4.77) | 0.299 | 2.48 (0.45–13.73) | 0.298 |
| Education level | ||||||||
| Under junior high school | Reference | Reference | Reference | Reference | ||||
| Over high school | 1.72 (0.62–4.77) | 0.299 | 2.20 (0.60–8.10) | 0.238 | 1.72 (0.62–4.77) | 0.299 | 2.20 (0.60–8.10) | 0.238 |
| Smoke history | ||||||||
| Never smoker | Reference | Reference | Reference | Reference | ||||
| Former smoker | 0.81 (0.33–1.97) | 0.635 | 1.47 (0.32–6.89) | 0.623 | 0.81 (0.33–1.97) | 0.635 | 1.47 (0.32–6.89) | 0.632 |
| Current smoker | 0.96 (0.38–2.47) | 0.940 | 1.70 (0.37–7.89) | 0.495 | 0.96 (0.38–2.47) | 0.940 | 1.70 (0.37–7.89) | 0.495 |
| Biofuel exposure | ||||||||
| No | Reference | Reference | Reference | Reference | ||||
| Yes | 0.98 (0.48–2.00) | 0.962 | 0.84 (0.32–2.18) | 0.720 | 0.98 (0.48–2.00) | 0.962 | 0.84 (0.32–2.18) | 0.720 |
| FEV1 %pred | 0.99 (0.96–1.01) | 0.177 | 0.98 (0.95–1.01) | 0.270 | 0.99 (0.96–1.01) | 0.177 | 0.98 (0.95–1.01) | 0.270 |
| CAT | 1.12 (1.05–1.19) | <0.001 | 1.16 (1.07–1.25) | <0.001 | 1.12 (1.05–1.19) | <0.001 | 1.16 (1.07–1.25) | <0.001 |
| mMRC | 1.06 (0.75–1.49) | 0.746 | 0.49 (0.28–0.87) | 0.016 | 1.06 (0.75–1.49) | 0.746 | 0.49 (0.28–0.87) | 0.016 |
| Exacerbations in the past year | 1.01 (0.92–1.11) | 0.806 | 1.01 (0.91–1.12) | 0.908 | 1.01 (0.92–1.11) | 0.806 | 1.01 (0.91–1.12) | 0.908 |
MCIDa- LAMA as the reference; MCIDb- LABA+ICS as the reference; aP values, after adjusting for sex, age, education level, smoke history, biofuel exposure, CAT, mMRC, FEV1 %pred, and exacerbation in the past year. The bold p-values indicate statistical significance.
BMI, body mass index; CAT, COPD Assessment Test; CI, confidence interval; FEV1, forced expiratory volume in one second; ICS, inhaled corticosteroid; LAMA, long-acting muscarinic antagonist; LABA, long-acting β2-agonist; mMRC, modified Medical Research Council; MCID, minimal clinically important difference; aOR, adjusted odds ratio.