Impact of the expression of NOX4 and TGFB1 on different parameters in HCC patients. HCC patients n = 124 from HUB. A) Distribution of the patients according to the expression of TGFB1 and NOX4. B) Pearson correlation analysis between NOX4 and TGFB1 gene expression in 120 patients for which we had data of survival: TGFB1 High/NOX4 High (green: 33 patients); TGFB1 High/NOX4 Low (blue: 27 patients); TGFB1 Low/NOX4 High (purple, 28 patients); TGFB1 High/NOX4 High (red, 32 patients). C) Kaplan-Meier curve for overall survival percentage when TGFB1 and NOX4 expression are high/low. D) Percentage of HCC patients that have a tumor size bigger or smaller than 5 cm when TGFB1 expression is high, depending on their NOX4 expression. E) Percentage of HCC patients in each histological grade (I-IV) when TGFB1 expression is high, depending on their NOX4 expression. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)