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. 2023 Jul 13;14:1218506. doi: 10.3389/fphar.2023.1218506

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Copyright © 2023 Gumbar, Bhardwaj, Mehan, Khan, Narula, Kalfin, Tabrez, Zughaibi and Wasi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nephroprotective potential of GA in the restoration of gross pathological changes in the kidney in gentamicin-treated rats; normal group renal tubules within normal limits, glomeruli within normal limits, no degenerative or atypical changes seen (A); gentamicin treated group showing the severe tubular necrosis, glomerular mesangial hypercellularity, focal hemorrhage and chronic inflammation (B); Renal tubules in vitamin E treated rats were within normal limits, glomeruli were within normal limits, and no degenerative or atypical changes were observed (C). In the GA-20 treated group kidney showed tubular and glomerular degenerative changes (mild to moderate), degeneration is more in the renal cortex than the medulla (D); in the GA -60 treated group kidney showed structure near to normal (E).