Fig. 1.

Spike-specific binding antibody (S-specific Ab) concentrations following each vaccination. S-specific Ab concentrations following severe acute respiratory syndrome coronavirus 2 vaccine in the solid cancer patients (CPs) and healthcare workers (HCWs) (A) after vaccination in CPs and HCWs receiving either mRNA or adenovirus vector vaccine. Comparison of binding antibody concentrations between CPs and HCWs stratified by the type of primary vaccination set after the first vaccination (B), after the second vaccination (C), and after the third vaccination (D). Antibody levels are represented as U/mL, and described as geometric mean with 95% confidence interval. Statistical analyses within each group were performed using the 2-tailed Mann-Whitney test. The Ca-mRNA group received a primary set of mRNA vaccines (either BNT162b2 or mRNA-1273), and the Ca-AdV group received a primary set of adenovirus vector vaccines (AZD1222); HCW-mRNA and HCW-AdV are groups of age-matched HCWs who received a primary series of mRNA vaccines and adenovirus vector vaccines, respectively. Each circle indicates the reciprocal binding antibody titer. ns, no significance; *p < 0.05, **p < 0.01, ***p < 0.001.