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. 2023 Jul 18;120(30):e2306572120. doi: 10.1073/pnas.2306572120

Fig. 1.

Fig. 1.

AQP4-specific Th17 cells from AQP4-deficient, but not from WT, mice induce CNS autoimmune disease. (A) WT mice are resistant to AQP4 CNS autoimmune disease by direct immunization with AQP4 (13, 14, 17, 18). Donor WT AQP4-specific T cells do not induce CNS autoimmune disease in WT recipient mice. In contrast, donor AQP4-specific T cells from AQP4-deficient mice induce short-lived clinical and histologic CNS autoimmune disease in recipient WT mice. (B) WT mice are susceptible to MOG CNS autoimmune disease (i.e., EAE) induced by immunization with MOG or by adoptive transfer donor WT MOG-specific T cells. Graphics created using BioRender.com.