Table 1.

Homology of pathogenic AQP4 T cell epitopes with other aquaporins

			Identity‡
Protein	Position*	Sequence*,†	Sequence (%)	Core (%)	Organs§
AQP4	133–149	LYLVTPPSVVGGLGVT			CNS, kidney, salivary gland, heart, GI tract, muscle, and lung
AQP6	115–131	LYGVTPGGIRETLGVN	50	44	Brain and kidney
AQP4	202–218	LFAINYTGASMNPARSF
AQP1	181–197	LLAIDYTGCSINPARSF	77	78	CNS, kidney, heart, lung, GI tract, ovary, testis, liver, muscle, and spleen
AQP4	202–218	LFAINYTGASMNPARSF
AQP2	173–189	LLGIYFTGCSMNPARSL	65	78	Kidney, ear, and ductus deferens
AQP4	202–218	LFAINYTGASMNPARSF
AQP5	174–190	LVGIYFTGCSMNPARSF	71	78	Salivary gland, eye, trachea, lung, GI tract, ovary, and kidney
AQP4	202–218	LFAINYTGASMNPARSF
AQP6	182–198	LIGIYFTGCSMNPARSF	71	78	Brain and kidney

^*Each mouse aquaporin was aligned individually to AQP4 using the Clustal Omega Multiple Sequence Alignment Tool (Clustal Omega < Multiple Sequence Alignment < EMBL-EBI), and homologous regions were identified.

^†Identical residues are identified in bolded black, and core binding regions are underlined.

^‡The % homology for the sequence listed and the binding region is listed.

^§Ref. (5).