Diaz 2001.

Methods	Study design : quasi‐randomised controlled trial
Participants	Country : Spain Setting : hospital Number of centres : 1 Numbers : AngioSeal 75, manual compression 75 Age (mean (SD)) : AngioSeal 59 (9.5) years, manual compression 60 (9) years Sex : AngioSeal 65 M/10 F, manual compression 64 M/11 F Inclusion criteria : patients aged over 18 years undergoing coronary angiography and/or percutaneous transluminal coronary angioplasty (PTCA) via the femoral artery with or without implantation of stent Exclusion criteria : the drilling of the posterior wall of the artery during puncture, presence of a femoral murmur, history of aortic vascular surgery or lower limb and the presence of haematoma before randomisation
Interventions	Intervention 1 : AngioSeal Intervention 2 : manual compression Sheath size : 6 Fr
Outcomes	Primary : time to haemostasis; time to ambulation Secondary : Hhaematoma
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	Sequence generated by odd and even numbers
Allocation concealment (selection bias)	High risk	Allocation based on alternation
Blinding of participants and personnel (performance bias) All outcomes	Low risk	No blinding, but review authors judged that outcomes and outcome measurements are not likely to be influenced by lack of blinding
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information to permit judgement of high or low risk
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No missing data
Selective reporting (reporting bias)	Unclear risk	Data on pre‐specified outcomes reported
Other bias	Low risk	Study appears to be free from other sources of bias