Table 1.

Histopathological parameters for assessment of cecal or colonic inflammation. Each sample is investigated for the described parameters and multiplied by the factor of the respective extent. The total score is a sum score of each parameter multiplied by the extent. Abbreviations: lamina propria, LP; submucosa, SM.

A. Mononuclear inflammation	Description	Area affected (extent)	Total (max. score)
0 1 2 3	Absent (normal sparse lymphocytic infiltrate) Mild (diffuse increase in LP) Moderate (LP with increased basal immune aggregates displacing crypts) Severe (LP with submucosal infiltrate)	0 – 4	(12)
B. Neutrophilic inflammation
0 1 2 3	None Mild (LP only) Moderate (LP and cryptitis/crypt abscesses) Sheet-like or submucosal infiltration	0 – 4	(9)
C. Submucosal edema/width
0 1 2 3	No pathological changes Mild (less than 50% of the diameter of the intestinal wall) Moderate (SM accounts for 50–80% of the intestinal wall diameter) Severe (SM accounts for >80% of the diameter of the intestinal wall)	0 – 4	(12)
D. Epithelial injury
0 1 2 3	None Mild (crypt dropout, epithelial desquamation) Moderate (focal ulceration) Severe (multifocal or extensive ulceration)	0 – 4	(9)
	Total (sum score)		0–42

Additional notes for affected area/extent:

0 1 2 3 4

None < 10 % of section < 10–25 % of section < 25–50 % of section > 50% of section