Figure 2. HS Association Plots for 2 Loci With European LD.

Variants associated with hidradenitis suppurativa (HS) in the 3-way meta-analysis located at the chromosome (chr) 17 locus (A) and the chr13 locus (B). Each point corresponds to 1 variant; the x-axis indicates genomic position, and the y-axis shows the −log₁₀(P value) of variant association with HS, and the size of each point indicates relative sample size analyzed for that variant. Variants are colored according to their linkage disequilibrium (LD) r² with the most significant variant in each region, which is shown as a purple diamond. The LD r² values are based on TOPMed European-ancestry individuals. Lines point to variants located in skin enhancers (see Figure 3). The nearest protein-coding genes are not located within the 400-kilobase regions shown.