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. 2023 Jul 26;159(9):930–938. doi: 10.1001/jamadermatol.2023.2217

Figure 3. Candidate Genes and Regulatory Variants at 2 Hidradenitis Suppurativa Loci.

Figure 3.

Variants at the chromosome (chr) 17 locus (A) are located in an intergenic region more than 600 kb from SOX9. Among candidate variants, rs17226067, rs17825774, and rs17825799 (blue rectangle) are located in a regulatory region conserved across vertebrate species and characterized by DNase I hypersensitivity (accessible chromatin) and epigenomic marks of enhancers in NHEK epidermal keratinocytes (ENCODE consortium). Variants at the chr13 locus (B) are located in an intergenic region between KLF5 and KLF12, and candidate variant rs61957178 (blue rectangle) is located in a regulatory region characterized by epigenomic marks of enhancers in NHEK epidermal keratinocytes.