Table 2. Summary Statistics of the Lead Variant at the 3 Suggestive Loci in 3-Way Meta-Analysis (MA).
| Variant | Chromosome:position (hg38) | Effect allelea | Effect allele frequencyb | OR 3-way MAc | P value, 3-way MA | OR BioVU replication | P value, BioVU replication | OR 4-way MA | P value, 4-way MA |
|---|---|---|---|---|---|---|---|---|---|
| rs10512572 | chr17:71515958 | A | 0.13 | 1.17 | 1.8 × 10−8 | 1.23 | 4.3 × 10−4 | 1.19 | 2.3 × 10−11 |
| rs17090189 | chr13:73432270 | A | 0.84 | 1.14 | 1.7 × 10−7 | 1.10 | .07 | 1.14 | 2.1 × 10−8 |
| rs5792315 | chr11:64223524 | A | 0.45 | 1.10 | 8.9 × 10−7 | 0.99 | .88 | 1.08 | 6.6 × 10−6 |
Abbreviations: HS ProCARE, Hidradenitis Suppurativa Program for Research and Care Excellence; OR, odds ratio; UKB, UK Biobank.
a
Represents 1 of the 4 alleles of human genetic variation (A, C, G, T).
b
Effect allele frequency is the weighted average across HS ProCARE, UKB, FinnGen, and BioVU.
c
Odds ratio is calculated based on the effective sample sizes (Methods).