Table 1.
Overview of study cohort. Data indicate median (interquartile range) or absolute numbers (percentage).
| Characteristics | Patients with Delta breakthrough infection (N=25) | Patients with Omicron-BA.1 breakthrough infection (N=15) | Patients with Omicron-BA.5 breakthrough infection (N=12) | Uninfected controls (N=28) | p |
|---|---|---|---|---|---|
| Sex: | |||||
| Men (%) | 17 (68) | 10 (66.7) | 4 (33.3) | 14 (50) | n.s. |
| Women (%) | 8 (32) | 5 (33.3) | 8 (66.7) | 14 (50) | |
| Age: | |||||
| Total | 73 (51-82) | 60 (55-77) | 69 (62-79) | 53 (49-63) | C-BA.5 and C-D: p<0.01 |
| 2 doses of vaccine | 71 (49-83) | 58 (44-63) | N/A | 52 (48-64) | C-D: p=0.0457 |
| Booster vaccination | 71 (60-81) | 74 (55-82) | 69 (62-79) | 54 (50-61) | C-BA.1 and C-BA.5: p<0.01 |
| Vaccine: | |||||
| Comirnaty® (BioNTech/Pfizer) (%) | 23 (92) | 8 (53.3) | 6 (50) | 15 (53.6) | D-BA.1, D-BA.5 and C-D: p<0.01 |
| Spikevax® (Moderna) (%) | 1 (4) | 2 (13.3) | 0 | 12 (42.9) | C-BA.5 and C-D: p<0.01 |
| Janssen® (Johnson & Johnson) (%) | 1 (4) | 0 | 0 | 0 | n.s. |
| Combination (%) | 0 | 5 (33.3) | 5 (41.7) | 1 (3.6) | D-BA-1, D-BA-5 and C-BA.5: p<0.01; C-BA.1: p<0.05 |
| Unknown (%) | 0 | 0 | 1 (8.3) | 0 | n.s. |
| Vaccine doses: | |||||
| 1 (%) | 1 (4) | 1 (6.7) | 0 | 0 | n.s. |
| 2 (%) | 22 (88) | 8 (53.3) | 0 | 16 (57.1) | D-BA.1 and C-D: p<0.05; D-BA.5: p<0.0001; BA.1-BA.5: 0.01; C-BA.5: p<0.001 |
| 3 (%) | 2 (8) | 6 (40) | 10 (83.3) | 10 (35.7) | D-BA.1, BA.1-BA.5, C-D and C-BA.5: p<0.05; D-BA.5: p<0.0001 |
| 4 (%) | 0 | 0 | 2 (16.7) | 2 (7.1) | n.s. |
| Days since vaccination: | |||||
| Total | 149.5 (97-184.3) | 134.5 (66.25-192.5) | 184.5 (133-222.5) | 186 (45.75-199.5) | n.s. |
| Since 2nd vaccination | 160 (113-188) | 176 (90.5-229.3) | N/A | 54 (29-186) | D-C: p=0.0414 |
| Since booster | 96.5 (91-102) | 69 (46-140) | 184.5 (133-222.5) | 199 (192.3-208) | D-BA.5, BA.1-BA.5 and D-C: p<0.05; C-BA.1: p<0.01 |
| Unknown | 7 | 1 | 4 | 0 | |
Data indicate median (interquartile range) or absolute numbers (percentage).
Differences between groups for the categorical variables were analyzed by Fisher’s exact test and for the continuous variables by two-tailed Mann-Whitney U test. N/A, not applicable; D, Delta; C, uninfected control; n.s., not significant.