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. 2023 Mar 29;13(7):3054–3066. doi: 10.1016/j.apsb.2023.03.022

Table 3.

Effect of 9a‒9g on WT HIV-1 RT.

Compd. IC50 (μmol/L)a Compd. IC50 (μmol/L)a
9a 0.035 ± 0.008 9f 0.021 ± 0.006
9b 0.027 ± 0.002 9g 0.021 ± 0.001
9c 0.021 ± 0.008 NVP 0.404 ± 0.07
9d 0.033 ± 0.002 EFV 0.030 ± 0.02
9e 0.029 ± 0.003 ETR 0.011 ± 0.01
a

IC50: inhibitory concentration of test compound required to inhibit wild-type HIV-1 reverse transcriptase polymerase activity by 50%. Values are the mean ± SD of at least two parallel tests. The data were obtained from the same laboratory (Prof. Erik De Clercq, Rega Institute for Medical Research).