Table 3.
Effect of 9a‒9g on WT HIV-1 RT.
| Compd. | IC50 (μmol/L)a | Compd. | IC50 (μmol/L)a |
|---|---|---|---|
| 9a | 0.035 ± 0.008 | 9f | 0.021 ± 0.006 |
| 9b | 0.027 ± 0.002 | 9g | 0.021 ± 0.001 |
| 9c | 0.021 ± 0.008 | NVP | 0.404 ± 0.07 |
| 9d | 0.033 ± 0.002 | EFV | 0.030 ± 0.02 |
| 9e | 0.029 ± 0.003 | ETR | 0.011 ± 0.01 |
IC50: inhibitory concentration of test compound required to inhibit wild-type HIV-1 reverse transcriptase polymerase activity by 50%. Values are the mean ± SD of at least two parallel tests. The data were obtained from the same laboratory (Prof. Erik De Clercq, Rega Institute for Medical Research).