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Effect of 9g on CYP enzymes.
| Compd. | IC50 (μmol/L) |
|||||
|---|---|---|---|---|---|---|
| CYP1A2 | CYP2C9 | CYP2C19 | CYP2D6 | CYP3A4-T | CYP3A4-M | |
| 9g | >25 | >25 | 14.0 | >25 | >25 | >25 |
| RPV26 | 9.11 | 0.346 | 0.335 | 3.41 | 2.17 | |
| Reference | 0.042a | 0.529b | 1.57c | 0.0397d | 0.0452e | 0.0739f |
Phenacetin.
Tolbutamide
Mephenytoin
Dextromethorphan.
Testosterone, and.
Midazolam were selected as the reference drugs (substrate midazolam).
