Table 6.
PK profile of 9g in rata.
| Parameter | 10.0 mg/kg (p.o.) | 1.0 mg/kg (i.v.) |
|---|---|---|
| t1/2 (h) | 5.21 ± 3.02 | 1.50 ± 0.14 |
| Tmax (h) | 0.83 ± 0.29 | 0.08 ± 0.00 |
| Cmax (ng/mL) | 39.3 ± 8.04 | 296 ± 79.4 |
| AUC0‒t (h·ng/mL) | 159 ± 48.7 | 244 ± 24.5 |
| AUC0‒∞ (h·ng/mL) | 198 ± 38.6 | 247 ± 25.8 |
| MRT0‒t (h) | 3.91 ± 2.38 | 1.19 ± 0.16 |
| MRT0‒∞ (h) | 6.80 ± 2.79 | 1.33 ± 0.21 |
| F (%) | 8.01 ± 0.02 |
a
p.o.: oral administration; i.v.: intravenous injection; t1/2: half-life; Tmax: time at peak concentration; Cmax: peak concentration; AUC: area under the concentration-time curve; MRT: mean residence time; F: oral bioavailability.