Table 2.
In vitro antifungal activity photocaged iodiconazole analogues under light or non-light conditions (MIC80a, μg/mL).
| Compd. | Structure |
C. albicans SC5314 |
C. neoformas H99 |
||
|---|---|---|---|---|---|
| black | hvb | black | hvb | ||
| B1 | R1 = DMNB, R2 = I X = CH2 |
0.25 | <0.125 | 1 | 0.5 |
| B2 | R1 = DMNB, R2 = H X = (CH2)3 |
2 | <0.125 | 8 | 4 |
| B3 | R1 = DMNB, R2 = H X = (CH2)4 |
2 | <0.125 | 8 | 4 |
| B4 | R1 = DEACM, R2 = H X = (CH2)3 |
2 | 0.25 | >64 | 8 |
| B5 | R1 = DEACM, R2 = H X = (CH2)4 |
1 | 0.25 | 16 | 4 |
| b1 | R1 = H, R2 = I X = CH2 |
<0.125 | <0.125 | <0.125 | <0.125 |
| b2 | R1 = H, R2 = H X = (CH2)3 |
<0.125 | <0.125 | 2 | 2 |
| b3 | R1 = H, R2 = H X = (CH2)4 |
<0.125 | <0.125 | 1 | 1 |
| FLC | / | 0.25 | 0.25 | 1 | 1 |
a
The minimum concentration of the compound at which the inhibition rate is greater than or equal to 80%.
b
Light conditions: 365 nm, 25 mW/cm2, 3 min.