Skip to main content
. 2023 Jun 8;16(3):369–383. doi: 10.1016/j.jcmgh.2023.06.002

Figure 1.

Figure 1

Age-related IGF1 decline is associated with reduced KIT and ERK phosphorylation. (A) Age-associated reduction of serum IGF1 levels determined by ELISA between 2 and 24 months of age (8 mice/time point). ∗P < .05 vs 2-month-old using Kruskal–Wallis 1-way analysis of variance. (B) Reduced IGF1 protein in klotho mouse gastric lysates compared with WT controls and in old vs young mice (n = 6–9/group). The klotho and WT mice were used between 60 and 70 days of age. ACTB (actin beta) was used as a loading control. Statistical significance was determined using Mann–Whitney rank sum tests. ∗P < .05. Age-associated down-regulation of IGF1, ERK phosphorylation, KIT, ANO1, and ETV1 protein in gastric muscles of patients between 26 and 82 years of age in (C) men and (D) women.