Figure 4.

QQ plots and Lambda values for the originally combined TOPPIC and BIOM datasets following BMIQ and quantile normalization (A), followed by Combat correction for methylation chip (B) and location within each chip (C). MDS scaling plot of the first 2 principal components for the originally combined of TOPPIC and BIOM datasets following BMIQ and quantile normalization (D), followed by Combat correction for methylation chip (E), and location within each chip (F). Colors (blue, red) denote different experimental batches. Green labelled points denote technical replicates included across chips, plates, runs, and batches.