Figure 7.

(A) Aryl hydrocarbon receptor repressor ARHH/cg05575921 methylation in smokers and nonsmokers and exsmokers in the entire cohort (combined CD and control subjects in both cohorts). (B) Correlation plot between smoking and exsmoker/nonsmoker log fold change beta value in Gao et al meta-analysis and in the present study (DMPs, Holm P < .05, entire cohort CD and control subjects combined). (C) Venn diagram of overlapping probes in Gao et al meta-analysis, smokers versus nonsmokers (DMPs, Holm P < .05) in total cohort (CD and control subjects combined), Crohn’s disease patients only, and control subjects only. The 9 smoking-associated CpGs seen only in the Crohn’s cohort are listed in the box. (D) Venn diagram of Crohn’s disease versus control DMPs in the entire cohort without using smoking as a covariate, entire cohort using smoking as a covariate, and in the smoking-associated DMPs in the Crohn’s only cohort. There are 4 CpGs that overlap that are both associated with Crohn’s (vs control, DMPs) and smoking (smoking vs exsmoker/never smoker, DMPs) that are listed in the boxes.