Table 10.
Top 20 Smoking-Associated Methylation Probes
| logFC | P value | Adjusted P value | SYM | Feature | |
|---|---|---|---|---|---|
| cg05575921 | -0.108 | 1.27E-50 | 5.46E-45 | AHRR | Body |
| cg01940273 | -0.062 | 1.95E-41 | 8.38E-36 | ∗ | None |
| cg03636183 | -0.072 | 1.38E-35 | 5.92E-30 | F2RL3 | Body |
| cg06126421 | -0.071 | 1.24E-32 | 5.33E-27 | ∗ | None |
| cg05951221 | -0.068 | 8.27E-31 | 3.56E-25 | ∗ | None |
| cg21161138 | -0.040 | 6.87E-29 | 2.95E-23 | AHRR | Body |
| cg26703534 | -0.035 | 1.84E-28 | 7.89E-23 | AHRR | Body |
| cg21566642 | -0.056 | 2.24E-23 | 9.61E-18 | ∗ | None |
| cg03329539 | -0.031 | 4.73E-22 | 2.03E-16 | ∗ | None |
| cg14817490 | -0.043 | 2.91E-20 | 1.25E-14 | AHRR | Body |
| cg25648203 | -0.029 | 6.33E-20 | 2.72E-14 | AHRR | Body |
| cg04885881 | -0.040 | 7.50E-20 | 3.23E-14 | ∗ | None |
| cg09935388 | -0.063 | 9.17E-19 | 3.94E-13 | GFI1 | Body |
| cg19572487 | -0.033 | 3.40E-18 | 1.46E-12 | RARA | 5'UTR |
| cg07826859 | -0.026 | 4.95E-17 | 2.13E-11 | MYO1G | TSS1500 |
| cg14753356 | -0.035 | 5.37E-17 | 2.31E-11 | ∗ | None |
| cg25189904 | -0.054 | 9.99E-17 | 4.30E-11 | GNG12 | TSS1500 |
| cg07339236 | -0.028 | 2.45E-16 | 1.05E-10 | ATP9A | Body |
| cg00310412 | -0.027 | 2.85E-16 | 1.22E-10 | SEMA7A | Body |
| cg23079012 | -0.024 | 7.46E-16 | 3.21E-10 | ∗ | None |
NOTE. Linear model smokers versus exsmokers and nonsmokers including age, sex, and cell admixture as covariates. Data include all patients and control subjects in combined cohort (CD and control subjects). Adjusted P value is Holm correction for multiple testing.
logFC, log fold change.