Table 4.

Top Table of Differentially Variable Positions in Patients With Disease Recurrence Postresection for CD Using Clinical End Point^a

	Gene symbol	Chr	Feature	Mean beta no recurrence	Mean beta recurrence	Mean diff	P value.t
cg24696067	MAD1L1	7	Body	-0.003	0.015	0.018	6.43E-05
cg02208776	HSPE1	2	1stExon	0.004	-0.018	-0.022	0.001
cg18068256	KRT37	17	Body	0.005	-0.022	-0.026	0.024
cg00475456	∗	1		0.003	-0.014	-0.017	0.027
cg20310608	LOC284798	20	TSS200	-0.001	0.003	0.004	0.031

NOTE. Calculated with the iEVOR method. A matrix of residual methylation values of a linear model including the following covariates was used (age, sex, smoking status, treatment/placebo, cell proportions).

^aDefined as increase in Crohn’s disease activity index of more than 150 and an increase of 100 points from baseline measurement and institution of immunosuppressive treatment or further surgery.