Table 6.
Top Cis meQTLs Associated With DMP (black) and DVP (grey) Methylation Probes, Most Significant SNP is Listed (age, sex, smoking status used as covariates)
| SNP | Methylation probe/annotation symbol | Statistic | P value | FDR corrected P value | beta |
|---|---|---|---|---|---|
| rs4796640 | cg18068256 / KRT37 | 8.2 | 1.77E-14 | 9.33E-08 | 0.07 |
| rs17169047 | cg02208776 / HSPE1 | -6.2 | 2.34E-09 | 0.003 | -0.06 |
| rs5996534 | cg24696067 / MAD1L1 | 5.5 | 1.32E-07 | 0.09 | 0.04 |
| rs2242144 | cg00475456 /∗ | 5.4 | 1.48E-07 | 0.09 | 0.03 |
| rs1298529 | cg23939096/∗ | 5.3 | 2.50E-07 | 0.09 | 0.04 |
| rs17827411 | cg25981920 /∗ | 5.2 | 3.87E-07 | 0.12 | 0.01 |
| rs11067376 | cg06058618 / ENFA3 | 5.0 | 1.16E-06 | 0.24 | 0.03 |
NOTE. MAF of <10% filtered. Cis distance 1 × 106, P value threshold <2 × 10-6.
DMP, differentially methylated position; DVP, differentially variable position; FDR, false discovery rate; meQTL, methylated quantitative trait loci; SNP, single-nucleotide polymorphism.