Table 7.
Top Cis meQTLs Associated With Clinical End Point (Disease Recurrence) DMP (black) and DVP (grey) Methylation Probes, Top SNP is Listed
| SNP | Methylation probe | Statistic | P value | FDR corrected P value | Beta |
|---|---|---|---|---|---|
| rs7922288 | cg00475456 /∗ | 12.4 | 9.27E-27 | 4.89E-20 | 0.19 |
| rs765335 | cg18068256 / KRT37 | 7.6 | 1.30E-12 | 2.80E-08 | 0.23 |
| exm669428 | cg24864518 /∗ | 6.2 | 2.64E-09 | 1.23E-05 | 0.10 |
NOTE. Age, sex, smoking status used as covariates. MAF of <10% filtered. Cis distance 1 × 106, P value threshold <2 × 10-6.
DMP, differentially methylated position; DVP, differentially variable position; FDR, false discovery rate; meQTL, methylated quantitative trait loci; SNP, single-nucleotide polymorphism.