Table 8.
Top 20 Differentially Methylated Positions Crohn's Disease TOPPIC (n = 233) Versus Control Subjects BIOM Dataset (n = 198)
| logFC | sym | Feature | P value | Adjusted P value | |
|---|---|---|---|---|---|
| cg21155778 | -0.10 | FGD6 | TSS200 | 8.65E-50 | 3.72E-44 |
| cg17931986 | 0.07 | COL11A2 | 3'UTR | 2.23E-38 | 9.60E-33 |
| cg19755108 | 0.03 | UIMC1 | TSS1500 | 1.96E-37 | 8.44E-32 |
| cg19056176 | -0.06 | KIAA0513 | 5'UTR | 1.21E-36 | 5.21E-31 |
| cg14863978 | -0.04 | GBX1 | TSS200 | 1.30E-36 | 5.58E-31 |
| cg02159402 | -0.09 | GALNT11 | TSS200 | 4.71E-36 | 2.03E-30 |
| cg05410609 | -0.07 | CCDC85C | 5'UTR | 5.89E-35 | 2.53E-29 |
| cg15281724 | 0.06 | TXLNB | Body | 1.94E-34 | 8.32E-29 |
| cg19165344 | 0.03 | AP1B1 | TSS1500 | 2.82E-33 | 1.21E-27 |
| cg04450857 | -0.06 | EMX2OS | Body | 4.82E-33 | 2.07E-27 |
| cg17541922 | -0.04 | PRSS23 | 5'UTR | 7.18E-33 | 3.09E-27 |
| cg18100079 | 0.04 | ∗ | None | 1.49E-32 | 6.41E-27 |
| cg02951344 | -0.05 | SYTL2 | TSS200 | 3.66E-32 | 1.57E-26 |
| cg14910854 | 0.03 | LOC150776 | Body | 8.88E-32 | 3.82E-26 |
| cg11338426 | -0.05 | CRHR1 | 1stExon | 1.50E-31 | 6.45E-26 |
| cg03047400 | -0.06 | ∗ | None | 3.04E-31 | 1.31E-25 |
| cg18301538 | 0.04 | GBF1 | Body | 3.47E-31 | 1.49E-25 |
| cg21120539 | -0.04 | CTSZ | 1stExon | 3.79E-31 | 1.63E-25 |
| cg06996129 | -0.09 | ∗ | None | 5.89E-31 | 2.53E-25 |
| cg12216772 | -0.07 | ANUBL1 | 5'UTR | 1.02E-30 | 4.39E-25 |
NOTE. Age, sex, smoking, estimate cell proportion included as covariates in linear model. Holm adjusted P value.
logFC, log fold change.