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. 2023 May 18;16(3):411–429. doi: 10.1016/j.jcmgh.2023.05.002

Figure 2.

Figure 2

Nox4 protects against DSS-induced experimental colitis. (A) Experimental scheme for the DSS-induced murine colitis model. (B) Body weight loss for WT and Nox4-/- mice with DSS-induced colitis was measured daily (n = 6). (C) Survival probability of WT or Nox4-/- mice with DSS-induced colitis was assessed until day 14 (n = 6). (D) Macroscopic observation of the colons from WT and Nox4-/- mice with DSS-induced colitis killed on day 14. Colon lengths were assessed after the mice were killed. (E) Representative H&E staining images of colon tissues from DSS-induced colitis WT and Nox4-/- mice. (F) Colitis scoring for pathologic assessment in DSS-induced colitis WT and Nox4-/- mice: severity, inflammation severity (0–3); extent, inflammation extent (0, none; 1, mucosa; 2, submucosa; and 3, transmural), and epithelial change. (G) Disease activity index comprising assessment of body weight loss, stool consistency, and rectal bleeding measured daily. Data are expressed as means ± SD. ∗∗∗P < .005, and ∗∗∗∗P < .001 compared with WT.