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. 2023 May 18;16(3):411–429. doi: 10.1016/j.jcmgh.2023.05.002

Figure 4.

Figure 4

Immune cell infiltration in the WT and Nox4-/-mouse colon. (A) Immunohistochemistry with antibodies against F4/80 indicating M1 macrophages, CD164 indicating M2 macrophages, CD127 indicating lymphoid cells, and Ki-67 (bottom) indicating proliferating cells. (B) Sirius-red staining showing the fibrotic area in red (top). Immunolabeling with antibodies against Tenascin-C indicating fibrosis in the colon tissue (bottom). Each positive staining area and cell was measured by ImageJ and shown as a bar graph. The WT group (N = 3) is colored gray and the Nox4-/- group (N = 3) is colored red. Data are expressed as means ± SD. ∗P < .5, ∗∗P < .01, and ∗∗∗P < .005 compared with WT. Ki-67, marker of proliferation Ki(Kiel)-67.