TABLE 1.
Resource Utilization From the COMET-ICE Trial and Corresponding Unit Costs From Administrative Claims Data
| From COMET-ICE trial (Step 2) | ||||||
|---|---|---|---|---|---|---|
| All patients (%) | Placebo | Sotrovimab | ||||
| N = 1,057 | (100.0) | N = 529 | N = 528 | |||
| Any health care utilization, n (%) | 68 | (6.4) | 46 | (8.7) | 22 | (4.2) |
| Inpatient (> 24-hour hospitalizations ONLY), n (%) | 35 | (3.3) | 29 | (5.5) | 6 | (1.1) |
| No respiratory support or oxygen therapy only, n (%) | 27 | (77.1) | 21 | (72.4) | 6 | (100.0) |
| Cumulative LOS in days | 176 | 123 | 53 | |||
| Noninvasive ventilation, n (%) | 4 | (11.4) | 4 | (13.8) | 0 | (0.0) |
| Cumulative LOS in days | 64 | 64 | ||||
| Invasive MV, n (%) | 4 | (11.4) | 4 | (13.8) | 0 | (0.0) |
| Cumulative LOS in days | 77 | 77 | ||||
| ECMO, n (%) | 0 | (0.0) | 0 | (0.0) | 0 | (0.0) |
| Cumulative LOS in days | N/A | |||||
| Inpatient (≤ 24-hour hospitalizations ONLY)a, n (%) | 1 | (0.1) | 0 | (0.0) | 1 | (0.2) |
| No respiratory support/oxygen therapy, n (%) | 1 | (0.1) | 0 | (0.0) | 1 | (0.2) |
| Cumulative LOS in days | 2 | 0 | 2 | |||
| Outpatient, n (%) | 36 | (3.4) | 20 | (3.8) | 16 | (3.0) |
| Emergency department visit, n (%) | 15 | (1.4) | 9 | (1.7) | 6 | (1.1) |
| Cumulative number of visits | 17 | 9 | 8 | |||
| Home health care visit, n (%) | 1 | (0.1) | 0 | (0.0) | 1 | (0.2) |
| Cumulative LOS in days | 1 | 1 | ||||
| Internal medicine/GP, n (%) | 8 | (0.8) | 5 | (1.0) | 3 | (0.6) |
| Cumulative number of visits | 8 | 5 | 3 | |||
| Telehealth, n (%) | 10 | (1.0) | 5 | (1.0) | 5 | (1.0) |
| Cumulative number of visits | 10 | 5 | 5 | |||
| Urgent care, n (%) | 4 | (0.4) | 2 | (0.4) | 2 | (0.4) |
| Cumulative number of visitsb | 5 | 3 | 2 | |||
| Other, n (%) | 3 | (0.3) | 2 | (0.4) | 1 | (0.2) |
| Cumulative number of visitsc | 3 | 1 | 2 | |||
| Cumulative number of visitsd | 1 | 1 | 0 | |||
| From claims (Step 1) | ||||
| Unit cost per resource use | ||||
| Main | Sensitivity 1 | Sensitivity 2 | Sensitivity 3 | |
|---|---|---|---|---|
| Overall mean | Commercial mean | Overall mean | Commercial mean | |
| Any health care utilization | ||||
| Inpatient (> 24-hour hospitalizations ONLY) | ||||
| No respiratory support or oxygen therapy only | ||||
| Cumulative LOS in days | $4,831/day | $5,032/day | $4,103/day | $4,291/day |
| Noninvasive ventilation | ||||
| Cumulative LOS in days | $6,067/day | $6,067/day | $3,837/day | $3,837/day |
| Invasive MV | ||||
| Cumulative LOS in days | $6,660/day | $7,145/day | $5,963/day | $6,236/day |
| ECMO | ||||
| Cumulative LOS in days | N/A | |||
| Inpatient (≤24-hour hospitalizations ONLY)a | ||||
| No respiratory support/oxygen therapy | ||||
| Cumulative LOS in days | $4,831/day | $5,032/day | $4,103/day | $4,291/day |
| Outpatient | ||||
| Emergency department visit | ||||
| Cumulative number of visits | $1,197/visit | $1,212/visit | $945/visit | $983/visit |
| Home health care visit | ||||
| Cumulative LOS in days | $372/day | $301/day | $132/day | $137/day |
| Internal medicine/GP | ||||
| Cumulative number of visits | $110/visit | $110/visit | $92/visit | $92/visit |
| Telehealth | ||||
| Cumulative number of visits | $110/visit | $111/visit | $92/visit | $93/visit |
| Urgent care | ||||
| Cumulative number of visitsb | $110/visit | $110/visit | $92/visit | $92/visit |
| Other | ||||
| Cumulative number of visitsc | $110/visit | $110/visit | $92/visit | $92/visit |
| Cumulative number of visitsd | $110/visit | $111/visit | $92/visit | $93/visit |
a One participant in the treatment group had a ≤ 24-hour hospitalization. The cost of that hospitalization was not included in the primary objective results but was included in the secondary objective results (total costs). That participant had 2 consecutive days flagged as “in hospital” in the day-level status file, but the summary data suggested the participant was in the hospital for 1 day and ≤ 24 hours. Because 2 separate consecutive days were flagged as inpatient, the cost of that hospitalization for this participant was included as 2 × unit cost per day for consistency in method used to compute hospitalization costs.
b Procedure codes for urgent care visits were included in the unit costs for office visits; therefore, office visit unit costs were used.
c Other outpatient included “CXR done,” “EMS visit to house,” and “pulmonologist” (applied office visit unit cost for all 3 visits).
d Other outpatient included “speaking with pulmonologist” (applied telehealth unit cost).
COMET-ICE = COVID-19 Monoclonal antibody Efficacy Trial-Intent to Care Early; CXR = chest X-ray; ECMO = extracorporeal membrane oxygenation; EMS = emergency medical services; GP = general practitioner; LOS = length of stay; MV = mechanical ventilation; N/A = not applicable.