TABLE 1.

Epidemiology Base-Case Analysis

Parameter	Input	Source
Prevalence of T1D	4.83	Per 1,000a
US adults with T1D	1,400,000	CDC1
US children with T1D	187,000	CDC1
Prevalence of T2D on insulin	17.37	Per 1,000a
US adults and children with T2D	25,313,000	CDC1,b
Percent of people with T2D on insulin	22.53%	Selvin et al4,c
Incidence of SHE in people with T1D	0.387	Per person-year, average
In people on 3+ daily injections or pump therapy	0.408 per person-year	Gubitosi-Klug et al23
In people on 1-2 daily injections	0.366 per person-year	Gubitosi-Klug et al23
Incidence of SHE in people with T2D treated with insulin	0.583	Per person-year, weighted averaged
Median reported among people on basal regimens	0.04 per person-year	Seufert et al24
In people using MDI	0.23 per person-year	Herman et al25
In people using CSII	0.08 per person-year	Herman et al25
In all people with T2D on any insulin	1.05 per person-year	Edridge et al26

^a Assuming US population of 328,239,523 (US Census 2019). ⁴⁴

^bTotal reported with diabetes less total reported with T1D, as above.

^c Selvin et al report that 27.1% of people with diabetes are insulin treated; assuming all patients with T1D are insulin treated, the remaining use of insulin is attributed to the use of insulin in patients with T2D.4

^d Final row is weighted at 50% of total; all others are equally weighted.

CDC = Centers for Disease Control and Prevention; CSII = continuous subcutaneous insulin infusion; MDI = multiple daily injection; SHE = severe hypoglycemic event; T1D = type 1 diabetes mellitus; T2D = type 2 diabetes mellitus.