Table 1.
The number of genes in each specificity interval
|
Global expression specificity |
||||||
|---|---|---|---|---|---|---|
| 0.8–1.0 | 0.6–0.8 | 0.4–0.6 | 0.2–0.4 | 0–0.2 | Total | |
| All genes | 12,267 (49.14%) | 2727 (10.92%) | 2530 (10.13%) | 2641 (10.58%) | 4798 (19.22%) | 24,963 |
| Skewness ≤ 0 | 10,421 (99.20%) | 84 (0.80%) | 0 (0%) | 0 (0%) | 0 (0%) | 10,505 (42.08%) |
| Q10 ≥ 0.1 | 9692 (100%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 9692 (38.83%) |
| Q20 ≥ 0.1 | 12,002 (99.98%) | 3 (0.02%) | 0 (0%) | 0 (0%) | 0 (0%) | 12,005 (48.09%) |
| 2011 UEG ARRAY [10] | 2038 (99.66%) | 4 (0.20%) | 2 (0.10%) | 1 (0.05%) | 0 (0%) | 2045 (8.19%) |
| 2009 UEG SEQ [8] | 7703 (98.88%) | 59 (0.76%) | 13 (0.17%) | 13 (0.17%) | 2 (0.03%) | 7790 (31.21%) |
| 2014 UEG SEQ [7] | 8696 (97.60%) | 176 (1.98%) | 37 (0.42%) | 0 (0%) | 1 (0.01%) | 8910 (35.69%) |
| 2013 HK SEQ [5] | 3786 (99.82%) | 5 (0.13%) | 2 (0.05%) | 0 (0%) | 0 (0%) | 3793 (15.19%) |
| BodyMap SEGs [3] | 735 (20.75%) | 573 (16.17%) | 708 (19.98%) | 808 (22.81%) | 719 (20.29%) | 3543 (14.19%) |
| GTEx SEGs [3] | 1128 (27.96%) | 661 (16.39%) | 748 (18.54%) | 806 (19.98%) | 691 (17.13%) | 4034 (16.16%) |
| Essential genes [26] | 5356 (77.00%) | 548 (7.88%) | 430 (6.18%) | 345 (4.96%) | 277 (3.98%) | 6956 (27.87%) |
| Trait genes [27] | 2246 (72.33%) | 372 (11.98%) | 251 (8.08%) | 172 (5.54%) | 64 (2.06%) | 3105 (12.44%) |
| Genetic disease genes [28] | 9759 (61.42%) | 1862 (11.72%) | 1644 (10.35%) | 1443 (9.08%) | 1180 (7.43%) | 15,888 (63.65%) |
| DRUGABLE genes [33] | 1764 (40.84%) | 711 (16.46%) | 738 (17.09%) | 643 (14.89%) | 463 (10.72%) | 4319 (17.30%) |
| UEGs@1.0 category | 9687 (100%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 9687 (38.81%) |
| UEGs@0.1 category | 2272 (89.20%) | 275 (10.80%) | 0 (0%) | 0 (0%) | 0 (0%) | 2547 (10.20%) |
| MEG category | 307 (9.75%) | 2094 (66.48%) | 749 (23.78%) | 0 (0%) | 0 (0%) | 3150 (12.62%) |
| SEGs@1.0 category | 1 (0.03%) | 358 (11.71%) | 1771 (57.91%) | 928 (30.35%) | 0 (0%) | 3058 (12.25%) |
| SEGs@0.1 category | 0 (0%) | 0 (0%) | 10 (0.15%) | 1713 (26.27%) | 4798 (73.58%) | 6521 (26.12%) |
Note: “All genes” indicates total genes analyzed in this study; “UEG SEQ” indicates UEGs derived from an RNA-seq-based study; “HK SEQ” indicates HK genes derived from an RNA-seq-based study which takes into account the variability of gene expression; “UEG ARRAY” indicates UEGs derived from a microarray-based study. Q10, 10% percentile; Q20, 20% percentile; UEG, ubiquitously expressed gene; SEG, specifically expressed gene; MEG, moderately specific gene; HK, housekeeping.