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. 2023 Feb 8;13(7):3093–3105. doi: 10.1016/j.apsb.2023.02.002

Figure 4.

Figure 4

Biodistribution of Gal/IL-15@CaLN in CT26 tumor-bearing BALB/c-ic mice (A) Fluorescent images of Gal/IL-15@LN and Gal/IL-15@CaLN-treated mice. The mice were intravenously injected at a DiD dose of 0.5 mg/kg. (B) Quantification of average fluorescence intensity at tumors in vivo (n = 3) (C) Ex vivo fluorescence images of major organs and tumors at 24 and 120 h, respectively. (D) Ex vivo quantification of average fluorescence intensity in major organs and tumors at 24 h and (E) at 120 h (n = 3) (F) Examination of Gal/IL-15@LN and Gal/IL-15@CaLN in tumors. Scale bars, 250 μm. Data were expressed as mean ± SD. The statistical significance was displayed by two-sided unpaired Student's t-test. (∗P < 0.05).