Comparison 8. Leg ulcer: hyaluronic acid versus neutral vehicle.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
8.1 Complete wound healing (from 60 days up to 23 weeks)	4	526	Risk Ratio (M‐H, Random, 95% CI)	2.11 [1.46, 3.07]
8.2 Adverse events ‐ infection	3	425	Risk Ratio (M‐H, Random, 95% CI)	0.89 [0.53, 1.49]
8.3 Pain (VAS) reduction from baseline	3	337	Mean Difference (IV, Random, 95% CI)	‐8.55 [‐14.77, ‐2.34]
8.4 Change in ulcer size (45 days)	2	190	Mean Difference (IV, Random, 95% CI)	30.44 [15.57, 45.31]