Table 4. GI50 (μM) of Compounds 4, 2B, 5A, and TAM on 60 Different Cell Lines.
| cell line | 4 | 2B | 5A | TAM | |
|---|---|---|---|---|---|
| leukemia | CCRF-CEM | 0.79 | 1.7 | 4.17 | 3.16 |
| HL-60 (TB) | 0.64 | 1.15 | 3.89 | 2.51 | |
| K-562 | 0.38 | 1.06 | 0.98 | 1.99 | |
| MOLT-4 | 0.65 | 1.05 | 4.01 | 2.51 | |
| RPMI-8226 | 0.58 | 1.17 | 1.07 | 2.51 | |
| SR | 0.74 | 0.98 | 0.99 | 1.26 | |
| non-small-cell lung cancer | A549/ATCC | 0.78 | 3.88 | 4.52 | 3.98 |
| EKVX | 0.82 | 5.76 | 4.75 | 6.31 | |
| HOP-62 | 0.59 | 7.76 | 6.07 | 10.0 | |
| HOP-92 | 0.46 | 0.83 | 1.62 | 2.52 | |
| NCI-H226 | 2.75 | 7.7 | 4.99 | 10.0 | |
| NCI-H23 | 0.76 | 7.43 | 4.54 | 5.01 | |
| NCI-H322M | 0.91 | 6.43 | 5.03 | 7.94 | |
| NCI-H460 | 0.48 | 1.10 | 1.22 | 3.16 | |
| NCI-H522 | 0.85 | 6.56 | 5.31 | 6.31 | |
| colon cancer | COLO 205 | 2.44 | 0.92 | 1.00 | 2.15 |
| HCC-2998 | 0.75 | 8.74 | 2.03 | 3.16 | |
| HCT-116 | 0.62 | 0.86 | 3.03 | 3.98 | |
| HCT-15 | 0.74 | 1.44 | 1.19 | 3.16 | |
| HT29 | 0.85 | 1.06 | 1.36 | 2.51 | |
| KM12 | 0.58 | 2.55 | 4.16 | 3.16 | |
| SW-620 | 0.82 | 1.16 | 1.67 | 3.16 | |
| CNS cancer | SF-268 | 0.74 | 7.6 | 5.01 | 6.31 |
| SF-295 | 0.69 | 0.92 | 5.50 | 1.96 | |
| SF-539 | 0.60 | 4.08 | 4.77 | 5.01 | |
| SNB-19 | 0.96 | 1.88 | 5.04 | 6.31 | |
| SNB-75 | 0.78 | 6.02 | 3.47 | 5.01 | |
| U251 | 0.57 | 1.66 | 3.72 | 3.16 | |
| melanoma | LOX IMVI | 0.42 | 0.87 | 3.02 | 2.51 |
| MALME-3M | 0.54 | 1.20 | 3.68 | 3.16 | |
| M14 | 0.70 | 0.97 | 5.19 | 2.51 | |
| MDA-MB-435 | 0.60 | 3.28 | 4.52 | 3.16 | |
| SK-MEL-2 | 0.80 | 8.01 | 5.69 | 5.01 | |
| SK-MEL-28 | 0.81 | 1.33 | 4.85 | 3.98 | |
| SK-MEL-5 | 0.47 | n.d. | 4.40 | 2.51 | |
| UACC-257 | 0.94 | 7.93 | 4.24 | 3.16 | |
| UACC-62 | 0.50 | 1.14 | 5.19 | 6.31 | |
| ovarian cancer | IGROV1 | 0.84 | 3.09 | 3.73 | 5.01 |
| OVCAR-3 | 0.67 | 3.27 | 4.53 | 3.98 | |
| OVCAR-4 | 0.77 | 5.25 | 3.52 | 6.31 | |
| OVCAR-5 | 2.90 | 6.54 | 4.79 | 6.31 | |
| OVCAR-8 | 0.99 | 8.05 | 5.75 | 7.94 | |
| NCI/ADR-RES | 0.69 | 7.27 | 4.80 | 5.01 | |
| SK-OV-3 | 1.04 | 10.02 | 5.42 | 10.0 | |
| renal cancer | 786–0 | 0.66 | 0.77 | 4.55 | 3.98 |
| A498 | 3.12 | 5.5 | ND | 6.31 | |
| ACHN | 3.71 | 5.61 | 5.12 | 6.31 | |
| CAKI-1 | 1.01 | 5.55 | 4.63 | 3.98 | |
| RXF 393 | 0.50 | 1.16 | 3.45 | 2.51 | |
| SN12C | 0.51 | 5.05 | 4.18 | 3.98 | |
| TK-10 | 2.75 | 6.23 | 5.10 | 3.98 | |
| UO-31 | 0.65 | 5.30 | 4.27 | 6.31 | |
| prostate cancer | PC-3 | 0.77 | 1.12 | 4.34 | 3.16 |
| DU-145 | 1.10 | 3.48 | 4.74 | 6.31 | |
| breast cancer | MCF7 | 0.82 | 1.05 | 1.70 | 1.58 |
| MDA-MB-231/ATCC | 0.97 | 1.30 | 4.27 | 6.31 | |
| HS 578T | 0.60 | 7.08 | 4.72 | 3.98 | |
| BT-549 | 0.50 | 1.13 | 4.95 | 6.31 | |
| T-47D | 0.89 | 3.75 | 3.83 | 2.51 | |
| MDA-MB-468 | 0.67 | 1.06 | 2.97 | 1.96 | |
| mean | 2.51 | 3.67 | 3.92 | 4.41 | |
| median | 0.75 | 3.09 | 4.34 | 3.98 |