Table 2.

List of approaches for improvement of future ICH-trials

Approaches for improvement of future trials
- Improving selection criteria: o Limitation of max. eligible time from symptom onset to randomization/intervention (< 4.5 h) o Limitation of max. eligible ICH-volume on initial imaging (< 60ml) o Stratify for antithrombotic medication o Stratification of ICH locations o Radiological predictors (non-contrast and contrast medium imaging markers o Development of AI-based risk prediction models
- Standardizing the definition of HE (stratified according to ICH location)
- Endpoint selection: o Functional outcome assessment at ≥6 months o Shift analysis models for HE and outcome instead of dichotomization o Patient-oriented continuous outcome variable (e.g. QALYs) o Composite endpoints of radiological and clinical endpoints

Approaches for improvement of future trials

- Improving selection criteria:

o Limitation of max. eligible time from symptom onset to randomization/intervention (< 4.5 h)

o Limitation of max. eligible ICH-volume on initial imaging (< 60ml)

o Stratify for antithrombotic medication

o Stratification of ICH locations

o Radiological predictors (non-contrast and contrast medium imaging markers

o Development of AI-based risk prediction models

- Standardizing the definition of HE (stratified according to ICH location)

- Endpoint selection:

o Functional outcome assessment at ≥6 months

o Shift analysis models for HE and outcome instead of dichotomization

o Patient-oriented continuous outcome variable (e.g. QALYs)

o Composite endpoints of radiological and clinical endpoints