Table 6.

Nigella sativa toxicity in humans

Substance	Concentration	Exposure route/period	Case history	Main results	Reference
Pure oil of black cumin	Not specified	Used on the neck for 3 months	28-year-old man for treatment of sore throat	Allergic contact dermatitis	[60]
EO of the seeds of black cumin	Not specified	Repeatedly applied as an ointment	31-year-old woman with an 8-month history of eczema on both hands	Allergic contact dermatitis	[61]
Capsules of BCEO	Containing 500 mg of organic N. sativa oil and 7.5 mg of vitamin E	Daily 15 days	56-year-old woman	Severe bullous target-like lesions, compatible with erythema multiforme	[80]

EO, essential oil.