Table 4.
Multivariable analysis of factors related to current 1chemotherapy-induced peripheral neuropathy in the Detroit Research on Cancer Survivors (ROCS) cohort
| aOR* | Lower CI | Upper CI | |
|---|---|---|---|
|
| |||
| Demographics | |||
| Age at Diagnosis (per age group) Marital Status | 0.77 | 0.62 | 0.96 |
| Married or equivalent | 1.31 | 0.94 | 1.84 |
| Widowed | 1.31 | 0.80 | 2.15 |
| Divorced or separated | 1.90 | 1.32 | 2.75 |
| Never married | ref | ||
| Educational Attainment (per category) | 0.97 | 0.86 | 1.10 |
| Cancer Characteristics | |||
| Cancer Site | |||
| Breast | 3.09 | 1.59 | 6.03 |
| Colorectal | 3.62 | 1.80 | 7.29 |
| Lung | 0.94 | 0.46 | 1.93 |
| Prostate | ref | ||
| SEER Summary Stage | |||
| Local | 0.57 | 0.37 | 0.89 |
| Regional | 0.78 | 0.53 | 1.16 |
| Distant | ref | ||
| Trend | 1.34 | 1.08 | 1.66 |
| Medical history | |||
| Body Mass Index (BMI) at Enrollment (per category) | 0.99 | 0.82 | 1.20 |
| Comorbidity count | |||
| None | ref | ||
| 1 | 1.07 | 0.63 | 1.82 |
| 2 | 1.16 | 0.68 | 1.98 |
| 3 | 1.66 | 0.92 | 2.99 |
| 4 or more | 2.08 | 1.15 | 3.76 |
| Trend | 1.23 | 1.09 | 1.40 |
| Diabetes mellitus | |||
| Yes | 1.03 | 0.72 | 1.48 |
| No | ref | ||
| Thyroid problem | |||
| Yes | 0.93 | 0.60 | 1.45 |
| No | ref | ||
| Arthritis | |||
| Yes | 1.09 | 0.80 | 1.49 |
| No | ref | ||
| Smoker (≥ 100 cigs lifetime) | |||
| Yes | 1.23 | 0.92 | 1.64 |
| No | ref | ||
| Alcohol use (in the past 4 weeks) | |||
| Yes | 0.92 | 0.70 | 1.21 |
| No | ref | ||
*
Multivariable adjustment for age at diagnosis, marital status, cancer site, BMI at enrollment, comorbidity count, and arthritis
1
Current CIPN was defined as CIPN occurring among individuals who experienced pain, numbness or tingling in hands or feet at the time of the survey. This analysis was based on 552 (53.4%) with current peripheral neuropathy compared to 482 individuals who did not report current peripheral neuropathy
Bold values denote statistical significance at p<0.05