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. Author manuscript; available in PMC: 2024 Apr 1.
Published in final edited form as: Headache. 2023 Mar 29;63(4):517–522. doi: 10.1111/head.14493

Table 2.

Association between gender-affirming hormone therapy and headache status among 273 transfeminine adolescents and 490 transmasculine adolescents.

Group: with headache without headache overall sample Odds Ratio

Transfeminine, n (%)

  treated with estrogen 9 (7) 114 (93) 123 (45) 5.8 (1.24–27.6)*
  untreated 2 (1) 148 (99) 150 (55)

Total 11 (4) 262 (96) 273 (100)

Transmasculine n (%)

  treated with testosterone 28 (12) 199 (88) 227 (46) 2.71 (1.37–5.4)**
  untreated 13 (5) 250 (95) 263 (54)

Total 41 (8) 449 (92) 490 (100)

95% confidence interval Woolf exact method, significance 2‐sided Fisher’s exact test.

*

p-value is 0.026

**

p-value is 0.005.