TABLE 4.

Percentage of MUT needed to detect a 3-fold increase in the EC₅₀ or IC₅₀ values compared to the respective WT virus

Mixture	% of MUT needed to detect 3-fold increase vs WT by:
	Plaque reduction assay in MDCK-SIAT1 cells	Minigenome assay	Virus yield reduction assay in NHBE cells
IAV WT:MUT I38L	35	66	49
IAV WT:MUT I38T	16	31	13
IAV WT:MUT E199D	-a	-	92
IBV WT:MUT I38T	82	20	10

^a- Not applicable.