FIG 4.
Serum viral loads at 2 dpi do not correlate with susceptibility to neuroinvasive flaviviruses. 9 to 12-week-old male and female mice were infected with 100 FFU of POWV strain MB5/12 (A and B), WNV strain NY2000 (C), or JEV strain Nakayama (D) via subcutaneous inoculation in the footpad. The mice were bled at 2 dpi, and viremia was assessed via qRT-PCR. Asterisks represent statistical significance (*, P < 0.05; ***, P < 0.001) via a one-way ANOVA, compared to CC045 (panels A, C, and D). The CC lines in panels A, C, and D are all Oas1b-null. The CC lines in panel B are Oas1b+/+. Open symbols denote surviving mice. The bar indicates the median.