TABLE 5.
Relative risk and population-attributable fraction of risk factors for all-cause dementia and AD dementia.
| Risk factor prevalence | All-cause dementia | AD dementia | |||
| RRa (95% CI) | PAF | RRa (95% CI) | PAF | ||
| Hypertension | 40.10% | 1.08 (1.04–1.11) | 2.9% (1.7–4.1) | 1.06 (1.02–1.10) | 2.3% (0.8–3.8) |
| Diabetes | 23.20% | 1.19 (1.16–1.22) | 4.2% (3.5–4.9) | 1.18 (1.14–1.22) | 4.0% (3.1–4.9) |
| Depression | 8.50% | 1.25 (1.21–1.30) | 2.1% (1.7–2.5) | 1.29 (1.24–1.35) | 2.4% (2.0–3.1) |
| Osteoporosis | 12.20% | 1.10 (1.07–1.13) | 1.2% (0.8–1.6) | 1.08 (1.04–1.12) | 1.0% (0.5–1.5) |
| Physical inactivity | 73.30% | 1.12 (1.09–1.15) | 8.1% (6.1–10.1) | 1.12 (1.08–1.16) | 8.2% (5.6–10.7) |
| Ischemic stroke | 5.00% | 1.19 (1.14–1.23) | 0.9% (0.7–1.1) | 1.12 (1.07–1.19) | 0.6% (0.3–0.9) |
| Hemorrhagic stroke | 0.60% | 1.09 (0.97–1.23) | 1.22 (1.05–1.42) | 0.1% (0.0–0.2) | |
| Hyperlipidemia | 35.60% | 1.02 (0.99–1.05) | 1.01 (0.97–1.05) | ||
| Coronary heart disease | 8.10% | 0.99 (0.96–1.02) | 0.99 (0.95–1.03) | ||
| Smoking | 55.90% | 1.03 (0.99–1.07) | |||
| Obesity | 37.10% | 0.93 (0.90–0.96) | 0.91 (0.88–0.95) | ||
AD, Alzheimer’s disease; RR, relative risk; CI, confidence interval; PAF, population-attributable fraction.
aAdjusted for sex, age, and each risk factor.