Table 2.
Univariate and multivariate analysis of RFS within 2 years.
| Characteristics | Total (N) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value | Hazard ratio (95% CI) | P value | ||
| Gender | 162 | ||||
| Female | 37 | Reference | |||
| Male | 125 | 1.154 (0.611-2.179) | 0.658 | ||
| Age | 162 | ||||
| ≤60 | 107 | Reference | |||
| >60 | 55 | 1.104 (0.642-1.898) | 0.720 | ||
| BMI>28 | 162 | ||||
| ≤28 | 143 | Reference | |||
| >28 | 19 | 1.848 (0.873-3.916) | 0.109 | ||
| Diabetes | 162 | ||||
| No | 151 | Reference | |||
| Yes | 11 | 0.485 (0.151-1.552) | 0.222 | ||
| Drinking history | 162 | ||||
| No | 130 | Reference | |||
| Yes | 32 | 1.432 (0.795-2.578) | 0.232 | ||
| HBSAg(+) | 162 | ||||
| No | 27 | Reference | |||
| Yes | 135 | 0.748 (0.387-1.443) | 0.386 | ||
| Tumor number | 162 | ||||
| Solitary | 138 | Reference | |||
| Multiple | 24 | 0.887 (0.420-1.872) | 0.754 | ||
| Tumor diameter (5cm) | 162 | ||||
| ≤5 | 101 | Reference | |||
| >5 | 61 | 1.700 (1.015-2.845) | 0.044 | 1.338 (0.763-2.343) | 0.309 |
| Differentiation | 162 | ||||
| Moderate and well | 102 | Reference | |||
| poor | 60 | 2.438 (1.449-4.103) | <0.001 | 2.043 (1.152-3.623) | 0.014 |
| Vascular invasion | 162 | ||||
| No | 147 | Reference | |||
| Yes | 15 | 3.053 (1.519-6.136) | 0.002 | 1.959 (0.936-4.097) | 0.074 |
| Cirrhosis | 162 | ||||
| No | 26 | Reference | |||
| Yes | 136 | 0.574 (0.304-1.085) | 0.087 | ||
| AJCC Staging | 162 | ||||
| I-II | 154 | Reference | |||
| III-IV | 8 | 1.609 (0.581-4.456) | 0.360 | ||
| Postoperative treatment (Ablation or TACE) | 162 | ||||
| No | 135 | Reference | |||
| Yes | 27 | 1.274 (0.687-2.364) | 0.442 | ||
| SIRI | |||||
| ≤0.785 | 93 | Reference | |||
| >0.785 | 69 | 2.738 (1.609-4.660) | <0.001 | 1.690 (0.848-3.368) | 0.136 |
| PLR | 162 | ||||
| ≤86.421 | 74 | Reference | |||
| >86.421 | 88 | 3.060 (1.649-5.676) | <0.001 | 1.758 (0.859-3.600) | 0.123 |
| NLR | 162 | ||||
| ≤2.231 | 98 | Reference | |||
| >2.231 | 64 | 2.613 (1.536-4.443) | <0.001 | 1.113 (0.554-2.238) | 0.763 |
| SII | 162 | ||||
| ≤353.64 | 93 | Reference | |||
| >353.64 | 69 | 2.547 (1.497-4.334) | <0.001 | 1.319 (0.674-2.581) | 0.419 |
| AFP (ng/ml) | 162 | ||||
| ≤400 | 112 | Reference | |||
| >400 | 50 | 1.124 (0.649-1.946) | 0.676 | ||
SIRI, Systemic Inflammation Response Index; PLR, Platelet-to-Lymphocyte Ratio; NLR, Neutrophil-to-Lymphocyte Ratio; SII, Systemic Immune-Inflammation Index; BMI, Body mass index; N, Regional lymph node metastasis; AFP, alpha fetoprotein.