Table 1. Relationships between KLRB1 expression and clinical characteristics in breast cancers using chi-square and Fisher’s exact tests.
| Parameter | Variable | Number | High | Hprop | Low | Lprop | X2 | P value | Fisher |
|---|---|---|---|---|---|---|---|---|---|
| Age | <60 | 589 | 407 | (69.10) | 182 | (30.90) | 7.5489 | 0.0055 | 0.0064 |
| > =60 | 513 | 314 | (61.21) | 199 | (38.79) | ||||
| Gender | Female | 1090 | 716 | (65.69) | 374 | (34.31) | 3.0278 | 0.1269 | 0.1229 |
| Male | 12 | 5 | (41.67) | 7 | (58.33) | ||||
| Histological type | Infiltrating Ductal Carcinoma | 790 | 489 | (61.90) | 301 | (38.10) | 31.6993 | 0.0005 | 0.0005 |
| Infiltrating Lobular Carcinoma | 204 | 168 | (82.35) | 36 | (17.65) | ||||
| Other | 107 | 64 | (59.81) | 43 | (40.19) | ||||
| Molecular subtype | Basal | 142 | 96 | (67.61) | 46 | (32.39) | 22.9660 | 0.0005 | 0.0010 |
| HER2 | 67 | 46 | (68.66) | 21 | (31.34) | ||||
| LumA | 422 | 285 | (67.54) | 137 | (32.46) | ||||
| LumB | 194 | 98 | (50.52) | 96 | (49.48) | ||||
| Normal | 24 | 20 | (83.33) | 4 | (16.67) | ||||
| ER | Indeterminate | 2 | 2 | (100.00) | 0 | (00.00) | 5.3216 | 0.0565 | 0.0495 |
| Negative | 239 | 171 | (71.55) | 68 | (28.45) | ||||
| Positive | 813 | 523 | (64.33) | 290 | (35.67) | ||||
| PR | Indeterminate | 4 | 4 | (100.00) | 0 | (00.00) | 2.2839 | 0.3543 | 0.4108 |
| Negative | 345 | 231 | (66.96) | 114 | (33.04) | ||||
| Positive | 704 | 461 | (65.48) | 243 | (34.52) | ||||
| HER2 | Equivocal | 180 | 112 | (62.22) | 68 | (37.78) | 4.9448 | 0.1709 | 0.1784 |
| Indeterminate | 12 | 9 | (75.00) | 3 | (25.00) | ||||
| Negative | 565 | 392 | (69.38) | 173 | (30.62) | ||||
| Positive | 164 | 103 | (62.80) | 61 | (37.20) | ||||
| Menopause status | Inde | 34 | 17 | (50.00) | 17 | (50.00) | 12.9076 | 0.0045 | 0.0050 |
| Peri | 40 | 28 | (70.00) | 12 | (30.00) | ||||
| Post | 706 | 447 | (63.31) | 259 | (36.69) | ||||
| Pre | 231 | 171 | (74.03) | 60 | (25.97) | ||||
| T classification | T1 | 281 | 194 | (69.04) | 87 | (30.96) | 12.9644 | 0.0130 | 0.0140 |
| T2 | 640 | 411 | (64.22) | 229 | (35.78) | ||||
| T3 | 138 | 96 | (69.57) | 42 | (30.43) | ||||
| T4 | 40 | 20 | (50.00) | 20 | (50.00) | ||||
| TX | 3 | 0 | (00.00) | 3 | (100.0) | ||||
| N classification | N0 | 516 | 334 | (64.73) | 182 | (35.27) | 12.4067 | 0.0120 | 0.0200 |
| N1 | 367 | 239 | (65.12) | 128 | (34.88) | ||||
| N2 | 120 | 81 | (67.50) | 39 | (32.50) | ||||
| N3 | 79 | 60 | (75.95) | 19 | (24.05) | ||||
| NX | 20 | 7 | (35.00) | 13 | (65.00) | ||||
| M classification | M0 | 917 | 608 | (66.30) | 309 | (33.70) | 6.3475 | 0.0440 | 0.0540 |
| M1 | 22 | 9 | (40.91) | 13 | (59.09) | ||||
| MX | 163 | 104 | (63.80) | 59 | (36.20) | ||||
| Stage | I | 182 | 128 | (70.33) | 54 | (29.67) | 15.1199 | 0.0065 | 0.0050 |
| II | 626 | 395 | (63.10) | 231 | (36.90) | ||||
| III | 252 | 177 | (70.24) | 75 | (29.76) | ||||
| IV | 20 | 9 | (45.00) | 11 | (55.00) | ||||
| X | 14 | 5 | (35.71) | 9 | (64.29) | ||||
| Lymph node status | No | 28 | 17 | (60.71) | 11 | (39.29) | 0.5509 | 0.5467 | 0.5384 |
| Yes | 697 | 470 | (67.43) | 227 | (32.57) | ||||
| Margin status | Close | 31 | 23 | (74.19) | 8 | (25.81) | 1.0288 | 0.5947 | 0.6402 |
| Negative | 922 | 605 | (65.62) | 317 | (34.38) | ||||
| Positive | 79 | 53 | (67.09) | 26 | (32.91) | ||||
| Vital status | Deceased | 155 | 80 | (51.61) | 75 | (48.39) | 15.2153 | 0.0005 | 0.0002 |
| Living | 947 | 641 | (67.69) | 306 | (32.31) | ||||
| Radiation therapy | No | 445 | 274 | (61.57) | 171 | (38.43) | 4.3067 | 0.0395 | 0.0390 |
| Yes | 557 | 378 | (67.86) | 179 | (32.14) | ||||
| Neoadjuvant treatment | No | 1088 | 713 | (65.53) | 375 | (34.47) | 0.7754 | 0.3878 | 0.3901 |
| Yes | 13 | 7 | (53.85) | 6 | (46.15) | ||||
| Targeted molecular therapy | No | 46 | 20 | (43.48) | 26 | (56.52) | 8.6985 | 0.0040 | 0.0040 |
| Yes | 533 | 348 | (65.29) | 185 | (34.71) | ||||
| Sample type | Metastatic | 7 | 5 | (71.43) | 2 | (28.57) | 0.1100 | 1.0000 | 1.0000 |
| Primary Tumor | 1097 | 718 | (65.45) | 379 | (34.55) | ||||
| OS | 0 | 933 | 632 | (67.74) | 301 | (32.26) | 14.5851 | 0.0010 | 0.0002 |
| 1 | 154 | 80 | (51.95) | 74 | (48.05) | ||||
| RFS | 0 | 816 | 551 | (67.52) | 265 | (32.48) | 5.8253 | 0.0180 | 0.0220 |
| 1 | 96 | 53 | (55.21) | 43 | (44.79) |
Notes.
Abbreviations: Bold values of P < 0.05 indicate statistically significant correlations. When the expected frequency is lower than 1, the Fisher’s exact test result is selected.