TABLE 1.
Pharmacokinetic study of OST in rat plasma under oral and intranasal administration (n = 6).
| Group | OST (2.5 mg/kg) oral | OST (2.5 mg/kg) intranasal | OST/BO (2.5 mg/kg for each) oral | OST/BO (2.5 mg/kg for each) intranasal |
|---|---|---|---|---|
| AUC0-t (ng/L*min) | 3,948 ± 601 | 43,653 ± 6539** | 6,907 ± 985 | 45,405 ± 1711## |
| AUC0-∞ (ng/L*min) | 4,170 ± 610 | 43,771 ± 6461** | 7,009 ± 1,050 | 45,555 ± 1602## |
| MRT0-t (min) | 135.4 ± 15.6 | 39.0 ± 1.9 | 108.5 ± 7.7 | 38.6 ± 7.1 |
| MRT0-∞ (min) | 152.7 ± 23.9 | 40.27 ± 1.8 | 113.3 ± 11.4 | 40.0 ± 6.9 |
| T1/2 (min) | 64.8 ± 12.7 | 51.0 ± 13.5 | 45.4 ± 19.3 | 59.9 ± 13.5 |
| Vz/F (L/kg) | 57,199 ± 16,416 | 4,357 ± 1,607 | 23,179 ± 9,269 | 4,762 ± 1,212 |
| CLz/F (L/min/kg) | 607.5 ± 82.4 | 57.9 ± 8.2** | 361.7 ± 49.9 | 54.9 ± 1.9## |
| Cmax (ng/L) | 22.5 ± 0.5 | 1,144.5 ± 89.0*** | 54.2 ± 10.6 | 1,172.6 ± 158.3### |
*OST (2.5 mg/kg in gel) intranasal administration group compared with OST (2.5 mg/kg in corn oil) oral administration group; #OST/BO (2.5 mg/kg in gel) intranasal administration group compared with OST/BO (2.5 mg/kg in corn oil) oral administration group, *p < 0.05, **p < 0.01, ***p < 0.001.