TABLE 2.
Pharmacokinetic study of OST in rat CSF under oral and intranasal administration (n = 6).
| Group | OST (2.5 mg/kg) oral | OST (2.5 mg/kg) intranasal | OST/BO (2.5 mg/kg for each) oral | OST/BO (2.5 mg/kg for each) intranasal |
|---|---|---|---|---|
| AUC0-t (ng/L*min) | 2,811 ± 703 | 10,083 ± 1158*** | 2090 ± 278 | 19,148 ± 3362###&& |
| AUC0-∞ (ng/L*min) | 3,547 ± 1,135 | 12,448 ± 1685*** | 2,377 ± 295 | 28,167 ± 19,055###&& |
| MRT0-t (min) | 112.1 ± 14.4 | 111.7 ± 6.2 | 98.2 ± 9.2 | 119.9 ± 5.1 |
| MRT0-∞ (min) | 150.1 ± 33.7 | 159.7 ± 22.1 | 128.3 ± 13.5 | 186.0 ± 110.4 |
| T1/2 (min) | 81.8 ± 25.2 | 86.8 ± 15.2 | 69.6 ± 15.2 | 141.2 ± 227.0 |
| Vz/F (L/kg) | 86,867 ± 29,137 | 25,231 ± 3,354 | 107,306 ± 29,386 | 12,801 ± 10,031 |
| CLz/F (L/min/kg) | 755.0 ± 193.6 | 204.2 ± 29.6*** | 1,066.3 ± 141.3 | 109.5 ± 38.0###& |
| Cmax (ng/L) | 21.8 ± 6.1 | 76.9 ± 10.8*** | 18.9 ± 4.3 | 177.2 ± 45.1###&& |
*OST (2.5 mg/kg in gel) intranasal administration group compared with OST (2.5 mg/kg in corn oil) oral administration group; #OST/BO (2.5 mg/kg for each) intranasal administration group compared with OST/BO (2.5 mg/kg for each) oral administration group; &OST/BO (2.5 mg/kg for each) oral intranasal administration group compared with OST (2.5 mg/kg) intranasal administration group, *p < 0.05, **p < 0.01, ***p < 0.001, # p < 0.05, ## p < 0.01, ### p < 0.001, & p < 0.05, && p < 0.01, &&& p < 0.001 (n = 6).