Fig. 1.

Earliest time of onset (indicated as the week of initial antidepressant effect) and longest duration of antidepressant efficacy (indicated as the longest period, that is, weeks, months, or years, of sustained antidepressant effect) reported for the included drugs in at least study. For psilocybin, zuranolone, and esmethadone, data are available on the onset of therapeutic effect before the first week of treatment. For AXS-05, PH-10, pimavanserin, seltorexant (MIN-202), and PRAX-114 there are no data about a possible early onset of the therapeutic effect (i.e. during the first hours or first days of treatment). BUP, bupropion; d, day; DXM, dextromethorphan; hr, hour; mth, month; wk, week; yr, year.