|
LncRNA
|
m6A regulators
|
Type
|
Cancer type
|
LncRNA role
|
Regulator role
|
Mechanism
|
References
|
| LINC00470 |
METTL3 |
writer |
Gastric cancer |
Oncogene |
Oncogene |
LINC00470 promotes METTL3-mediated PTEN mRNA degradation |
[136] |
| LINC00942 |
METTL14 |
writer |
Breast cancer |
Oncogene |
Oncogene |
Recruits METTL14 to mediate CXCR4 and CYP1B1 mRNA stability. |
[255] |
| GATA3-AS |
KIAA1429 |
writer |
Hepatocellular carcinoma |
Oncogene |
Oncogene |
Mediate interaction of KIAA1429 with GATA3 pre-mRNA to methylate and degrade GATA3 pre-mRNA |
[70] |
| UTM2A-AS1 |
METTL3 |
writer |
Lung adenocarcinoma |
Oncogene |
Oncogene |
Regulates the miR-590-5p/METTL3 axis |
[256] |
| LINC00240 |
METTL3 |
writer |
Gastric cancer |
Oncogene |
Oncogene |
Modulates miR-338-5p/METTL3 axis |
[257] |
| BLACAT2 |
METTL3 |
writer |
Gastric cancer |
Oncogene |
Oncogene |
Modulates miR-193b-5p/METTL3 |
[258] |
| IFL3-AS1 |
METTL3 |
writer |
Hepatocellular carcinoma |
Oncogene |
Oncogene |
Inhibits the degradation of ILF3 mRNA |
[259] |
| FOXM1-AS |
ALKBH5 |
eraser |
Glioblastoma |
Oncogene |
Oncogene |
Promotes the interaction of ALKBH5 with FOXM1 to enhance demethylation of FOXM1 |
[80] |
| GAS5-AS1 |
ALKBH5 |
eraser |
Cervical cancer |
Tumor suppressor gene |
Tumor suppressor gene |
Interacts with ALKBH5 to demethylate GAS5 to promote tumor suppressor gene GAS5 stability |
[260] |
| MALAT1 |
IGF2BP2 |
reader |
Thyroid cancer |
Oncogene |
Oncogene |
miR-204/IGF2BP2/m6A-MYC |
[134] |
| LINRIS |
IGF2BP2 |
reader |
Colorectal cancer |
Oncogene |
Oncogene |
LINRIS maintains the stability of IGF2BP2 |
[135] |
| KB-1980E6.3 |
IGF2BP1 |
reader |
Breast cancer stem cells |
Oncogene |
Oncogene |
Recruits IGF2BP1 to mediate c-Myc mRNA stability. |
[137] |
| LINC00857 |
YTHDC1 |
reader |
Colorectal cancer |
Oncogene |
Oncogene |
Interacts with YTHDC1 to stabilize SLC7A5 |
[261] |
| LIN28B-AS1 |
IGF2BP1 |
reader |
Hepatocellular carcinoma, lung adenocarcinoma |
Oncogene |
Oncogene |
Activate LIN28B by interacting with IGF2BP1 |
[262] |
| miR503HG |
HNRNPA2B1 |
reader |
Hepatocellular carcinoma |
Tumor suppressor gene |
Oncogene |
Promotes HNRNPA2B1 degradation |
[263] |
| DMDRMR |
IGF2BP3 |
reader |
Clear cell renal cell carcinoma |
Oncogene |
Oncogene |
Up-regulates m6A-modified CDK4 via interacting with IGF2BP3. |
[264] |
| LINC01234 |
HNRNPA2B1 |
reader |
Non-small-cell lung cancer |
Oncogene |
Oncogene |
Facilitates the processing of pri-miR-106b |
[265] |
