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. 2023 Jul 13;14:1211776. doi: 10.3389/fimmu.2023.1211776

Table 4.

Conformity of specific diagnostic criteria.

OCB Initial symptom Supporting clinical or MRI features Red flags Dissemination in space by MRI for MS
Periventricular Cortical or
juxtacortical
Infratentorial Spinal cord two or more
(-)1 Optic neuritis Optic neuritis; bilateral simultaneous clinical involvement
(-)2 Optic neuritis Optic neuritis; bilateral simultaneous clinical involvement +
(-)3 Optic neuritis Optic neuritis; bilateral simultaneous clinical involvement +
(-)4 Optic neuritis Optic neuritis; longitudinal optic nerve involvement
(-)5 Myelitis Myelitis; longitudinally extensive myelitis +
(-)6 Optic neuritis Optic neuritis; bilateral simultaneous clinical involvement +
(-)7 Optic neuritis Optic neuritis; longitudinal optic nerve involvement +
(-)8 Optic neuritis Optic neuritis; perineural optic sheath enhancement
(-)9 Optic neuritis Optic neuritis; longitudinal optic nerve involvement
(-)10 Myelitis Myelitis; longitudinally extensive myelitis +
(-)11 Myelitis Optic neuritis; bilateral simultaneous clinical involvement
(-)12 Optic neuritis Optic neuritis; bilateral simultaneous clinical involvement
(-)13 Optic neuritis Myelitis; H-sign Progressive course* + + + + +
(+)1 Brainstem Ill-defined T2-hyperintensity involving pons
(+)2 Epilepsy Cortical lesion +
(+)3 Optic neuritis Myelitis; H-sign
(+)4 Optic neuritis Optic neuritis; perineural optic sheath enhancement +
(+)5 Myelitis Myelitis; conus lesion +
(+)6 Myelitis Myelitis; H-sign +
(+)7 Brainstem Cortical lesion +
(+)8 Myelitis Cortical lesion DIS in MS-MRI criteria* + + +
(+)9 Myelitis Myelitis; Central cord lesion DIS in MS-MRI criteria* + + +
(+)10 Myelitis Myelitis; conus lesion Progressive course, DIS in MRI* + + + + +

OCB, oligoclonal band; DIS, dissemination in space; MS, multiple sclerosis. *The representative MRI findings are presented in Figure 3 .