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. 2023 Jul 13;11:1234763. doi: 10.3389/fchem.2023.1234763

TABLE 1.

Complete pathway for β-hydroxy amines synthesis 4a-g.

graphic file with name FCHEM_fchem-2023-1234763_wc_tfx1.jpg
Entry R 2 Yield of 3a-g (%) Yield of 4a-g (%)
1 -(CH2)2CH3 2a 95 95
2 -(CH2)6CH3 2b 88 89
3 -(CH2)10CH3 2c 86 86
4 a -CH2CH2Ph 2d 90 68
5 -Ph 2e 35 40
6 -OC=CH-CH=CH- 2f 43
7 -CH=CH-Ph 2g 74
a

Reaction carried out with 15mol% of TMG.