TABLE 1.
Complete pathway for β-hydroxy amines synthesis 4a-g.
| ||||
|---|---|---|---|---|
| Entry | R | 2 | Yield of 3a-g (%) | Yield of 4a-g (%) |
| 1 | -(CH2)2CH3 | 2a | 95 | 95 |
| 2 | -(CH2)6CH3 | 2b | 88 | 89 |
| 3 | -(CH2)10CH3 | 2c | 86 | 86 |
| 4 a | -CH2CH2Ph | 2d | 90 | 68 |
| 5 | -Ph | 2e | 35 | 40 |
| 6 | -OC=CH-CH=CH- | 2f | 43 | — |
| 7 | -CH=CH-Ph | 2g | 74 | — |
Reaction carried out with 15mol% of TMG.