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. 2023 Jul 13;13:1125592. doi: 10.3389/fonc.2023.1125592

Table 1.

Clinical characteristics of the patients studied.

Clinical characteristics Training set Testing set
Overall study population NOAF Without NOAF P value Overall study population NOAF Without NOAF P value
(n=807) group (n=89) group (n=718) (n=282) group (n=25) group (n=257)
Age (years) 65 (59-70) 68 (62-72) 64 (58-70) 0.003 64 (57-68) 69 (64-74) 63 (57-68) 0.001
Sex (%) <0.001 0.035
 Male 589 (73.0) 80 (89.9) 509 (70.9) 196 (69.5) 22 (88.0) 174 (67.7)
 Female 218 (27.0) 9 (10.1) 209 (29.1) 86 (30.5) 3 (12.0) 83 (32.3)
Hypertension (%) 138 (17.1) 27 (30.3) 111 (15.5) <0.001 47 (16.7) 5 (20.0) 42 (16.3) 0.582
Diabetes (%) 62 (7.7) 12 (13.5) 50 (7.0) 0.029 26 (9.2) 3 (12.0) 23 (8.9) 0.714
Coronary heart disease (%) 30 (3.7) 8 (9.0) 22 (3.1) 0.012 14 (5.0) 2 (8.0) 12 (4.7) 0.358
Smoking history (%) 289 (35.8) 53 (59.6) 236 (32.9) <0.001 102 (36.2) 14 (56.0) 88 (34.2) 0.031
Classification (%) <0.001 0.024
 CPC 312 (38.7) 54 (60.7) 258 (35.9) 110 (39.0) 15 (60.0) 95 (37.0)
 PPC 495 (61.3) 35 (39.3) 460 (64.1) 172 (61.0) 10 (40.0) 162 (63.0)
PE 115 (14.3) 22 (24.7) 93 (13.0) 0.003 43 (15.2) 8 (32.0) 35 (13.6) 0.035
Location (%) 0.471 0.816
 Left 352 (43.6) 42 (47.2) 310 (43.2) 119 (42.2) 10 (40.0) 109 (42.4)
 Right 455 (56.4) 47 (52.8) 408 (56.8) 163 (57.8) 15 (60.0) 148 (57.6)
Histology (%) 0.514 1.000
 NSCLC 638 (79.1) 68 (76.4) 570 (79.4) 239 (84.8) 21 (84.0) 218 (84.8)
 SCLC 169 (20.9) 21 (23.6) 148 (20.6) 43 (15.2) 4 (16.0) 39 (15.2)
Therapy 0.720 0.320
 Chemotherapy regimens 730 (90.5) 81 (91.0) 649 (90.4) 223 (79.1) 22 (88.0) 201 (78.2)
 Paclitaxel 72 (8.9) 6 (6.7) 66 (9.2) 53 (18.8) 7 (28.0) 46 (17.9)
 Others 658 (81.5) 75 (84.3) 583 (81.2) 170 (60.3) 15 (60.0) 155 (60.3)
Non-chemotherapy 77 (9.5) 8 (9.0) 69 (9.6) 59 (20.9) 3 (12.0) 56 (21.8)
CRP (mg/L) 3.53 (0.96-13.53) 9.81 (2.51-32.67) 3.21 (0.90-12.07) <0.001 5.11 (1.53-19.68) 11.98 (4.20-30.27) 4.91 (1.45-19.68) 0.030
Potassium (mmol/L) 4.1 (3.9-4.3) 4.1 (3.9-4.4) 4.1 (3.9-4.3) 0.451 4.0 (3.9-4.3) 4.2 (3.9-4.4) 4.0 (3.8-4.2) 0.109
TTE
LAD (mm) 35 (32-37) 35 (33-39) 35 (32-37) 0.042 36 (34-38) 36 (34-40) 36 (34-38) 0.185
LVESD (mm) 28 (26-30) 29 (27-30) 28 (26-30) 0.604 29 (27-32) 30 (28-33) 29 (27-32) 0.091
LVEDD (mm) 47 (44-49) 47 (45-49) 47 (44-49) 0.908 47 (44-50) 48 (46-48) 47 (44-50) 0.978
LVEF (%) 64 (62-65) 64 (62-65) 64 (62-65) 0.164 65 (63-67) 64 (61-65) 65 (64-67) 0.001

Data are presented as median (interquartile range) or n (%). NOAF, new-onset atrial fibrillation; CPC, centric pulmonary carcinoma; PPC, peripheral pulmonary carcinoma; PE, pericardial effusion; NSCLC, non-small cell lung cancer; SCLC, small cell lung cancer; CRP, c-reactive protein; TTE, transthoracic echocardiography; LAD, left atrial diameter; LVESD, left ventricular end diastolic diameter; LVEDD, left ventricular end diastolic diameter;LVEF, left ventricular ejection fraction.